Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

Proline-rich tyrosine kinase 2 (PYK2) can be activated by angiotensin II (Ang II) and reactive oxygen species. We report that in endothelial cells, Ang II enhances the tyrosine phosphorylation of endothelial NO synthase (eNOS) in an AT(1)-, H(2)O(2)-, and PYK2-dependent manner. Low concentrations (1...

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Detalles Bibliográficos
Autores principales: Loot, Annemarieke E., Schreiber, Judith G., Fisslthaler, Beate, Fleming, Ingrid
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806451/
https://www.ncbi.nlm.nih.gov/pubmed/19934023
http://dx.doi.org/10.1084/jem.20090449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806451/
https://www.ncbi.nlm.nih.gov/pubmed/19934023
http://dx.doi.org/10.1084/jem.20090449

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