Proteinase-activated receptor-2 mediated inhibition of TNFα-stimulated JNK activation — A novel paradigm for G(q/11) linked GPCRs

In this study we examined the potential for PAR(2) and TNFα to synergise at the level of MAP kinase signalling in PAR(2) expressing NCTC2544 cells. However, to our surprise we found that activation of PAR(2) by trypsin or the specific activating peptide SLIGKV-OH strongly inhibited both the phosphor...

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Detalles Bibliográficos
Autores principales: McIntosh, Kathryn, Cunningham, Margaret R., Cadalbert, Laurence, Lockhart, John, Boyd, Gary, Ferrell, W.R., Plevin, Robin
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806525/
https://www.ncbi.nlm.nih.gov/pubmed/19781631
http://dx.doi.org/10.1016/j.cellsig.2009.09.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806525/
https://www.ncbi.nlm.nih.gov/pubmed/19781631
http://dx.doi.org/10.1016/j.cellsig.2009.09.028

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