The glycosaminoglycan-binding domain of PRELP acts as a cell type–specific NF-κB inhibitor that impairs osteoclastogenesis

Proline/arginine-rich end leucine-rich repeat protein (PRELP) is a glycosaminoglycan (GAG)- and collagen-binding anchor protein highly expressed in cartilage, basement membranes, and developing bone. We observed that PRELP inhibited in vitro and in vivo mouse osteoclastogenesis through its GAG-bindi...

Descripción completa

Detalles Bibliográficos
Autores principales: Rucci, Nadia, Rufo, Anna, Alamanou, Marina, Capulli, Mattia, Del Fattore, Andrea, Åhrman, Emma, Capece, Daria, Iansante, Valeria, Zazzeroni, Francesca, Alesse, Edoardo, Heinegård, Dick, Teti, Anna
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806584/
https://www.ncbi.nlm.nih.gov/pubmed/19951916
http://dx.doi.org/10.1083/jcb.200906014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806584/
https://www.ncbi.nlm.nih.gov/pubmed/19951916
http://dx.doi.org/10.1083/jcb.200906014

Ejemplares similares