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Decreased replication origin activity in temporal transition regions

In the mammalian genome, early- and late-replicating domains are often separated by temporal transition regions (TTRs) with novel properties and unknown functions. We identified a TTR in the mouse immunoglobulin heavy chain (Igh) locus, which contains replication origins that are silent in embryonic...

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Detalles Bibliográficos
Autores principales: Guan, Zeqiang, Hughes, Christina M., Kosiyatrakul, Settapong, Norio, Paolo, Sen, Ranjan, Fiering, Steven, Allis, C. David, Bouhassira, Eric E., Schildkraut, Carl L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806585/
https://www.ncbi.nlm.nih.gov/pubmed/19951913
http://dx.doi.org/10.1083/jcb.200905144