An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis

Plasmalemmal phosphatidylinositol (PI) 4,5-bisphosphate (PI4,5P(2)) synthesized by PI 4-phosphate (PI4P) 5-kinase (PIP5K) is key to the polymerization of actin that drives chemotaxis and phagocytosis. We investigated the means whereby PIP5K is targeted to the membrane and its fate during phagosome f...

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Detalles Bibliográficos
Autores principales: Fairn, Gregory D., Ogata, Koji, Botelho, Roberto J., Stahl, Philip D., Anderson, Richard A., De Camilli, Pietro, Meyer, Tobias, Wodak, Shoshana, Grinstein, Sergio
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806594/
https://www.ncbi.nlm.nih.gov/pubmed/19951917
http://dx.doi.org/10.1083/jcb.200909025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806594/
https://www.ncbi.nlm.nih.gov/pubmed/19951917
http://dx.doi.org/10.1083/jcb.200909025

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