Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation

During somatic hypermutation (SHM), B cells introduce mutations into their immunoglobulin genes to generate high affinity antibodies. Current models suggest a separation in the generation of G/C transversions by the Ung2-dependent pathway and the generation of A/T mutations by the Msh2/ubiquitinated...

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Detalles Bibliográficos
Autores principales: Krijger, Peter H.L., Langerak, Petra, van den Berk, Paul C.M., Jacobs, Heinz
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806606/
https://www.ncbi.nlm.nih.gov/pubmed/19901081
http://dx.doi.org/10.1084/jem.20091707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806606/
https://www.ncbi.nlm.nih.gov/pubmed/19901081
http://dx.doi.org/10.1084/jem.20091707

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