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Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation
During somatic hypermutation (SHM), B cells introduce mutations into their immunoglobulin genes to generate high affinity antibodies. Current models suggest a separation in the generation of G/C transversions by the Ung2-dependent pathway and the generation of A/T mutations by the Msh2/ubiquitinated...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806606/ https://www.ncbi.nlm.nih.gov/pubmed/19901081 http://dx.doi.org/10.1084/jem.20091707 |