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The G protein βγ subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin
The inflammatory mediator thrombin proteolytically activates protease-activated receptor (PAR1) eliciting a transient, but reversible increase in vascular permeability. PAR1-induced dissociation of Gα subunit from heterotrimeric Gq and G12/G13 proteins is known to signal the increase in endothelial...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806626/ https://www.ncbi.nlm.nih.gov/pubmed/19917775 http://dx.doi.org/10.1084/jem.20090652 |