Modulation of Akt and ERK1/2 Pathways by Resveratrol in Chronic Myelogenous Leukemia (CML) Cells Results in the Downregulation of Hsp70

BACKGROUND: Resveratrol is known to downregulate the high endogenous level of Heat shock protein 70 (Hsp70) in Chronic Myelogenous Leukemia (CML) K562 cells and induce apoptosis. Since Heat Shock Factor 1 (HSF1) controls transcription of Hsp70, we wanted to probe the signaling pathways responsible f...

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Detalles Bibliográficos
Autores principales: Banerjee Mustafi, Soumyajit, Chakraborty, Prabir K., Raha, Sanghamitra
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806839/
https://www.ncbi.nlm.nih.gov/pubmed/20090934
http://dx.doi.org/10.1371/journal.pone.0008719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806839/
https://www.ncbi.nlm.nih.gov/pubmed/20090934
http://dx.doi.org/10.1371/journal.pone.0008719

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