Hypoxia Activates a Ca(2+)-Permeable Cation Conductance Sensitive to Carbon Monoxide and to GsMTx-4 in Human and Mouse Sickle Erythrocytes

BACKGROUND: Deoxygenation of sickle erythrocytes activates a cation permeability of unknown molecular identity (Psickle), leading to elevated intracellular [Ca(2+)] ([Ca(2+)](i)) and subsequent activation of K(Ca) 3.1. The resulting erythrocyte volume decrease elevates intracellular hemoglobin S (Hb...

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Detalles Bibliográficos
Autores principales: Vandorpe, David H., Xu, Chang, Shmukler, Boris E., Otterbein, Leo E., Trudel, Marie, Sachs, Frederick, Gottlieb, Philip A., Brugnara, Carlo, Alper, Seth L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806905/
https://www.ncbi.nlm.nih.gov/pubmed/20090940
http://dx.doi.org/10.1371/journal.pone.0008732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806905/
https://www.ncbi.nlm.nih.gov/pubmed/20090940
http://dx.doi.org/10.1371/journal.pone.0008732

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