Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface

Angiopoietin-1 (Ang1) and Ang2 are ligands for the receptor tyrosine kinase Tie2. Structural data suggest that the two ligands bind Tie2 similarly. However, in endothelial cells Ang1 activates Tie2 whereas Ang2 can act as an apparent antagonist. In addition, each ligand exhibits distinct kinetics of...

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Detalles Bibliográficos
Autores principales: Hansen, Tania M., Singh, Harprit, Tahir, Tariq A., Brindle, Nicholas P.J.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807028/
https://www.ncbi.nlm.nih.gov/pubmed/19922791
http://dx.doi.org/10.1016/j.cellsig.2009.11.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807028/
https://www.ncbi.nlm.nih.gov/pubmed/19922791
http://dx.doi.org/10.1016/j.cellsig.2009.11.007

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