An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

Mitosis is controlled by multiple protein kinases, many of which are abnormally expressed in human cancers. Nek2, Nek6, Nek7, and Nek9 are NIMA-related kinases essential for proper mitotic progression. We determined the atomic structure of Nek7 and discovered an autoinhibited conformation that sugge...

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Detalles Bibliográficos
Autores principales: Richards, Mark W., O'Regan, Laura, Mas-Droux, Corine, Blot, Joelle M.Y., Cheung, Jack, Hoelder, Swen, Fry, Andrew M., Bayliss, Richard
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807034/
https://www.ncbi.nlm.nih.gov/pubmed/19941817
http://dx.doi.org/10.1016/j.molcel.2009.09.038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807034/
https://www.ncbi.nlm.nih.gov/pubmed/19941817
http://dx.doi.org/10.1016/j.molcel.2009.09.038

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