Normal Proliferation and Tumorigenesis but Impaired Pancreatic Function in Mice Lacking the Cell Cycle Regulator Sei1

Sei1 is a positive regulator of proliferation that promotes the assembly of Cdk4-cyclin D complexes and enhances the transcriptional activity of E2f1. The potential oncogenic role of Sei1 is further suggested by its overexpression in various types of human cancers. To study the role of Sei1, we have...

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Detalles Bibliográficos
Autores principales: Fernandez-Marcos, Pablo J., Pantoja, Cristina, Gonzalez-Rodriguez, Agueda, Martin, Nicholas, Flores, Juana M., Valverde, Angela M., Hara, Eiji, Serrano, Manuel
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807453/
https://www.ncbi.nlm.nih.gov/pubmed/20090907
http://dx.doi.org/10.1371/journal.pone.0008744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807453/
https://www.ncbi.nlm.nih.gov/pubmed/20090907
http://dx.doi.org/10.1371/journal.pone.0008744

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