17-AAG Induces Cytoplasmic α-Synuclein Aggregate Clearance by Induction of Autophagy

BACKGROUND: The accumulation and aggregation of α-synuclein in nerve cells and glia are characteristic features of a number of neurodegenerative diseases termed synucleinopathies. α-Synuclein is a highly soluble protein which in a nucleation dependent process is capable of self-aggregation. The caus...

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Detalles Bibliográficos
Autores principales: Riedel, Michael, Goldbaum, Olaf, Schwarz, Lisa, Schmitt, Sebastian, Richter-Landsberg, Christiane
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807466/
https://www.ncbi.nlm.nih.gov/pubmed/20090920
http://dx.doi.org/10.1371/journal.pone.0008753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807466/
https://www.ncbi.nlm.nih.gov/pubmed/20090920
http://dx.doi.org/10.1371/journal.pone.0008753

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