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17-AAG Induces Cytoplasmic α-Synuclein Aggregate Clearance by Induction of Autophagy
BACKGROUND: The accumulation and aggregation of α-synuclein in nerve cells and glia are characteristic features of a number of neurodegenerative diseases termed synucleinopathies. α-Synuclein is a highly soluble protein which in a nucleation dependent process is capable of self-aggregation. The caus...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807466/ https://www.ncbi.nlm.nih.gov/pubmed/20090920 http://dx.doi.org/10.1371/journal.pone.0008753 |