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Analysis of the stoichiometric metal activation of methionine aminopeptidase
BACKGROUND: Methionine aminopeptidase (MetAP) is a ubiquitous enzyme required for cell survival and an attractive target for antibacterial and anticancer drug development. The number of a divalent metal required for catalysis is under intense debate. E. coli MetAP was shown to be fully active with o...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807865/ https://www.ncbi.nlm.nih.gov/pubmed/20017927 http://dx.doi.org/10.1186/1471-2091-10-32 |