Protein kinase C α and ε phosphorylation of troponin and myosin binding protein C reduce Ca(2+) sensitivity in human myocardium

Previous studies indicated that the increase in protein kinase C (PKC)-mediated myofilament protein phosphorylation observed in failing myocardium might be detrimental for contractile function. This study was designed to reveal and compare the effects of PKCα- and PKCε-mediated phosphorylation on my...

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Detalles Bibliográficos
Autores principales: Kooij, Viola, Boontje, Nicky, Zaremba, Ruud, Jaquet, Kornelia, dos Remedios, Cris, Stienen, Ger J. M., van der Velden, Jolanda
Formato: Texto
Lenguaje:English
Publicado: D. Steinkopff-Verlag 2009
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807945/
https://www.ncbi.nlm.nih.gov/pubmed/19655190
http://dx.doi.org/10.1007/s00395-009-0053-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807945/
https://www.ncbi.nlm.nih.gov/pubmed/19655190
http://dx.doi.org/10.1007/s00395-009-0053-z

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