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Protein kinase C α and ε phosphorylation of troponin and myosin binding protein C reduce Ca(2+) sensitivity in human myocardium

Previous studies indicated that the increase in protein kinase C (PKC)-mediated myofilament protein phosphorylation observed in failing myocardium might be detrimental for contractile function. This study was designed to reveal and compare the effects of PKCα- and PKCε-mediated phosphorylation on my...

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Detalles Bibliográficos
Autores principales:	Kooij, Viola, Boontje, Nicky, Zaremba, Ruud, Jaquet, Kornelia, dos Remedios, Cris, Stienen, Ger J. M., van der Velden, Jolanda
Formato:	Texto
Lenguaje:	English
Publicado:	D. Steinkopff-Verlag 2009
Materias:	Original Contribution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807945/ https://www.ncbi.nlm.nih.gov/pubmed/19655190 http://dx.doi.org/10.1007/s00395-009-0053-z

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