Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson’s Disease-Linked PARK7

Although a loss-of-function mutation has been identified in familial Parkinson’s disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we identified UCP0045037 as a compound that bound to the reduced form of DJ-1 by in silico virtual screenin...

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Detalles Bibliográficos
Autores principales: Yamane, Koichiro, Kitamura, Yoshihisa, Yanagida, Takashi, Takata, Kazuyuki, Yanagisawa, Daijiro, Taniguchi, Takashi, Taira, Takahiro, Ariga, Hiroyoshi
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808011/
https://www.ncbi.nlm.nih.gov/pubmed/20087465
http://dx.doi.org/10.3390/ijms10114789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808011/
https://www.ncbi.nlm.nih.gov/pubmed/20087465
http://dx.doi.org/10.3390/ijms10114789

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