Microtubules Regulate Migratory Polarity through Rho/ROCK Signaling in T Cells

BACKGROUND: Migrating leukocytes normally have a polarized morphology with an actin-rich lamellipodium at the front and a uropod at the rear. Microtubules (MTs) are required for persistent migration and chemotaxis, but how they affect cell polarity is not known. METHODOLOGY/PRINCIPAL FINDINGS: Here...

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Detalles Bibliográficos
Autores principales: Takesono, Aya, Heasman, Sarah J., Wojciak-Stothard, Beata, Garg, Ritu, Ridley, Anne J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808253/
https://www.ncbi.nlm.nih.gov/pubmed/20098744
http://dx.doi.org/10.1371/journal.pone.0008774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808253/
https://www.ncbi.nlm.nih.gov/pubmed/20098744
http://dx.doi.org/10.1371/journal.pone.0008774

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