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The Site Specific Demethylation in the 5′-Regulatory Area of NMDA Receptor 2B Subunit Gene Associated with CIE-Induced Up-Regulation of Transcription

BACKGROUND: The NMDA receptor represents a particularly important site of ethanol action in the CNS. We recently reported that NMDA receptor 2B (NR2B) gene expression was persistently up-regulated following chronic intermittent ethanol (CIE) treatment. Increasing evidence that epigenetic mechanisms...

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Detalles Bibliográficos
Autores principales: Qiang, Mei, Denny, Ashley, Chen, Jiguo, Ticku, Maharaj K., Yan, Bo, Henderson, George
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808353/
https://www.ncbi.nlm.nih.gov/pubmed/20098704
http://dx.doi.org/10.1371/journal.pone.0008798