Chemical reprogramming of Caenorhabditis elegans germ cell fate

Small-molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. We have chemically induced functional oocytes in C. elegans adults that otherwise produced only sperm. Th...

Descripción completa

Detalles Bibliográficos
Autores principales: Morgan, Clinton T., Lee, Myon-Hee, Kimble, Judith
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808631/
https://www.ncbi.nlm.nih.gov/pubmed/20081824
http://dx.doi.org/10.1038/nchembio.282
_version_ 1782176516838260736
author Morgan, Clinton T.
Lee, Myon-Hee
Kimble, Judith
author_facet Morgan, Clinton T.
Lee, Myon-Hee
Kimble, Judith
author_sort Morgan, Clinton T.
collection PubMed
description Small-molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. We have chemically induced functional oocytes in C. elegans adults that otherwise produced only sperm. These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell reprogramming.
format Text
id pubmed-2808631
institution National Center for Biotechnology Information
language English
publishDate 2009
record_format MEDLINE/PubMed
spelling pubmed-28086312010-08-01 Chemical reprogramming of Caenorhabditis elegans germ cell fate Morgan, Clinton T. Lee, Myon-Hee Kimble, Judith Nat Chem Biol Article Small-molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. We have chemically induced functional oocytes in C. elegans adults that otherwise produced only sperm. These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell reprogramming. 2009-12-20 2010-02 /pmc/articles/PMC2808631/ /pubmed/20081824 http://dx.doi.org/10.1038/nchembio.282 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Morgan, Clinton T.
Lee, Myon-Hee
Kimble, Judith
Chemical reprogramming of Caenorhabditis elegans germ cell fate
title Chemical reprogramming of Caenorhabditis elegans germ cell fate
title_full Chemical reprogramming of Caenorhabditis elegans germ cell fate
title_fullStr Chemical reprogramming of Caenorhabditis elegans germ cell fate
title_full_unstemmed Chemical reprogramming of Caenorhabditis elegans germ cell fate
title_short Chemical reprogramming of Caenorhabditis elegans germ cell fate
title_sort chemical reprogramming of caenorhabditis elegans germ cell fate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808631/
https://www.ncbi.nlm.nih.gov/pubmed/20081824
http://dx.doi.org/10.1038/nchembio.282
work_keys_str_mv AT morganclintont chemicalreprogrammingofcaenorhabditiselegansgermcellfate
AT leemyonhee chemicalreprogrammingofcaenorhabditiselegansgermcellfate
AT kimblejudith chemicalreprogrammingofcaenorhabditiselegansgermcellfate

Ejemplares similares