Retroviral vectors encoding ADA regulatory locus control region provide enhanced T-cell-specific transgene expression

BACKGROUND: Murine retroviral vectors have been used in several hundred gene therapy clinical trials, but have fallen out of favor for a number of reasons. One issue is that gene expression from viral or internal promoters is highly variable and essentially unregulated. Moreover, with retroviral vec...

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Detalles Bibliográficos
Autores principales: Trinh, Alice T, Ball, Bret G, Weber, Erin, Gallaher, Timothy K, Gluzman-Poltorak, Zoya, Anderson, French, Basile, Lena A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809042/
https://www.ncbi.nlm.nih.gov/pubmed/20042112
http://dx.doi.org/10.1186/1479-0556-7-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809042/
https://www.ncbi.nlm.nih.gov/pubmed/20042112
http://dx.doi.org/10.1186/1479-0556-7-13

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