Cargando…
Retroviral vectors encoding ADA regulatory locus control region provide enhanced T-cell-specific transgene expression
BACKGROUND: Murine retroviral vectors have been used in several hundred gene therapy clinical trials, but have fallen out of favor for a number of reasons. One issue is that gene expression from viral or internal promoters is highly variable and essentially unregulated. Moreover, with retroviral vec...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809042/ https://www.ncbi.nlm.nih.gov/pubmed/20042112 http://dx.doi.org/10.1186/1479-0556-7-13 |