HH Domain of Alzheimer’s Disease Aβ Provides Structural Basis for Neuronal Binding in PC12 and Mouse Cortical/Hippocampal Neurons

A key question in understanding AD is whether extracellular Aβ deposition of parenchymal amyloid plaques or intraneuronal Aβ accumulation initiates the AD process. Amyloid precursor protein (APP) is endocytosed from the cell surface into endosomes where it is cleaved to produce soluble Aβ which is t...

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Detalles Bibliográficos
Autores principales: Poduslo, Joseph F., Gilles, Emily J., Ramakrishnan, Muthu, Howell, Kyle G., Wengenack, Thomas M., Curran, Geoffry L., Kandimalla, Karunya K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809098/
https://www.ncbi.nlm.nih.gov/pubmed/20098681
http://dx.doi.org/10.1371/journal.pone.0008813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809098/
https://www.ncbi.nlm.nih.gov/pubmed/20098681
http://dx.doi.org/10.1371/journal.pone.0008813

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