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Intact Cytoskeleton Is Required for Small G Protein Dependent Activation of the Epithelial Na(+) Channel

BACKGROUND: The Epithelial Na(+) Channel (ENaC) plays a central role in control of epithelial surface hydration and vascular volume. Similar to other ion channels, ENaC activity is regulated, in part, by cortical cytoskeleton. Besides, the cytoskeleton is an established target for small G proteins s...

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Detalles Bibliográficos
Autores principales: Karpushev, Alexey V., Ilatovskaya, Daria V., Pavlov, Tengis S., Negulyaev, Yuri A., Staruschenko, Alexander
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809106/
https://www.ncbi.nlm.nih.gov/pubmed/20098689
http://dx.doi.org/10.1371/journal.pone.0008827