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Octamer binding protein 2 (Oct2) regulates PD-L2 gene expression in B-1 cells through lineage-specific activity of a unique, intronic promoter

PD-L2 expression extends beyond macrophages/dendritic cells to B-1 B cells, a distinct B cell lineage that is responsible for natural immunoglobulin and which is repertoire skewed toward autoreactive specificities. PD-L2 expression is constitutive in B-1 cells, whereas it is inducible in other cell...

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Detalles Bibliográficos
Autores principales: Kaku, Hiroaki, Rothstein, Thomas L.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809120/
https://www.ncbi.nlm.nih.gov/pubmed/19710692
http://dx.doi.org/10.1038/gene.2009.68