Determinants Present in the Receptor Carboxy Tail Are Responsible for Differences in Subtype-Specific Coupling of β-Adrenergic Receptors to Phosphoinositide 3-Kinase

An agonist-occupied β (2)-adrenergic receptor (β (2)-AR) recruits G protein receptor kinase-2 (GRK2) which is recruited to the membrane. Thus, the physical proximity of activated β (2)-AR and PI-3K allows the activation of the latter. In contrast, it has been observed that the β (1)-AR is unable to...

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Detalles Bibliográficos
Autores principales: Simard, Julie, Boucher, Matthieu, Massé, Rachel, Hébert, Terence E., Rousseau, Guy
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809356/
https://www.ncbi.nlm.nih.gov/pubmed/20130777
http://dx.doi.org/10.1155/2009/959168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809356/
https://www.ncbi.nlm.nih.gov/pubmed/20130777
http://dx.doi.org/10.1155/2009/959168

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