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Distinct Type of Transmission Barrier Revealed by Study of Multiple Prion Determinants of Rnq1

Prions are self-propagating protein conformations. Transmission of the prion state between non-identical proteins, e.g. between homologous proteins from different species, is frequently inefficient. Transmission barriers are attributed to sequence differences in prion proteins, but their underlying...

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Detalles Bibliográficos
Autores principales: Kadnar, Michele L., Articov, Gulnara, Derkatch, Irina L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809767/
https://www.ncbi.nlm.nih.gov/pubmed/20107602
http://dx.doi.org/10.1371/journal.pgen.1000824