Differential Requirement of CAAX-mediated Posttranslational Processing for Rheb Localization and Signaling

The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer and are attractive targets for anti-cancer drug discovery. Rheb is targeted to endomembranes via its C-terminal CAAX (C = cysteine, A = aliphatic, X = terminal amino acid) motif, a substrate for posttr...

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Detalles Bibliográficos
Autores principales: Hanker, Ariella B., Mitin, Natalia, Wilder, Rhonda S., Henske, Elizabeth Petri, Tamanoi, Fuyuhiko, Cox, Adrienne D., Der, Channing J.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809798/
https://www.ncbi.nlm.nih.gov/pubmed/19838215
http://dx.doi.org/10.1038/onc.2009.336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809798/
https://www.ncbi.nlm.nih.gov/pubmed/19838215
http://dx.doi.org/10.1038/onc.2009.336

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