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Differential Requirement of CAAX-mediated Posttranslational Processing for Rheb Localization and Signaling

The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer and are attractive targets for anti-cancer drug discovery. Rheb is targeted to endomembranes via its C-terminal CAAX (C = cysteine, A = aliphatic, X = terminal amino acid) motif, a substrate for posttr...

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Detalles Bibliográficos
Autores principales:	Hanker, Ariella B., Mitin, Natalia, Wilder, Rhonda S., Henske, Elizabeth Petri, Tamanoi, Fuyuhiko, Cox, Adrienne D., Der, Channing J.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809798/ https://www.ncbi.nlm.nih.gov/pubmed/19838215 http://dx.doi.org/10.1038/onc.2009.336

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