Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells

OBJECTIVE: Cytokines contribute to pancreatic β-cell death in type 1 diabetes. This effect is mediated by complex gene networks that remain to be characterized. We presently utilized array analysis to define the global expression pattern of genes, including spliced variants, modified by the cytokine...

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Detalles Bibliográficos
Autores principales: Ortis, Fernanda, Naamane, Najib, Flamez, Daisy, Ladrière, Laurence, Moore, Fabrice, Cunha, Daniel A., Colli, Maikel L., Thykjaer, Thomas, Thorsen, Kasper, Ørntoft, Torben F., Eizirik, Decio L.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809955/
https://www.ncbi.nlm.nih.gov/pubmed/19934004
http://dx.doi.org/10.2337/db09-1159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809955/
https://www.ncbi.nlm.nih.gov/pubmed/19934004
http://dx.doi.org/10.2337/db09-1159

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