Cargando…

Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells

OBJECTIVE: Cytokines contribute to pancreatic β-cell death in type 1 diabetes. This effect is mediated by complex gene networks that remain to be characterized. We presently utilized array analysis to define the global expression pattern of genes, including spliced variants, modified by the cytokine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ortis, Fernanda, Naamane, Najib, Flamez, Daisy, Ladrière, Laurence, Moore, Fabrice, Cunha, Daniel A., Colli, Maikel L., Thykjaer, Thomas, Thorsen, Kasper, Ørntoft, Torben F., Eizirik, Decio L.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809955/ https://www.ncbi.nlm.nih.gov/pubmed/19934004 http://dx.doi.org/10.2337/db09-1159

Ejemplares similares

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA
por: Colli, Maikel L., et al.
Publicado: (2010)

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB
por: Cunha, Daniel A., et al.
Publicado: (2009)

In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells
por: Naamane, Najib, et al.
Publicado: (2007)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
por: Santin, Izortze, et al.
Publicado: (2011)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis
por: Moore, Fabrice, et al.
Publicado: (2009)

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells
por: Alvelos, Maria Inês, et al.
Publicado: (2020)

Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells
por: Szymczak, Florian, et al.
Publicado: (2022)

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes
por: Colli, Maikel L., et al.
Publicado: (2020)

Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells
por: Kaur, Simranjeet, et al.
Publicado: (2022)

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
por: Szymczak, Florian, et al.
Publicado: (2022)

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim
por: Nogueira, Tatiane C., et al.
Publicado: (2013)

Detailed transcriptome atlas of the pancreatic beta cell
por: Kutlu, Burak, et al.
Publicado: (2009)

Checks and Balances—The Limits of β-Cell Endurance to ER Stress
por: Eizirik, Decio L., et al.
Publicado: (2017)

On the Immense Variety and Complexity of Circumstances Conditioning Pancreatic β-Cell Apoptosis in Type 1 Diabetes
por: Eizirik, Decio L., et al.
Publicado: (2012)

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis
por: Cunha, Daniel A., et al.
Publicado: (2012)

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells
por: Gurzov, Esteban N., et al.
Publicado: (2008)

Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis
por: Magnusson, Nils E, et al.
Publicado: (2005)

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature
por: Fignani, Daniela, et al.
Publicado: (2020)

Clic4, a novel protein that sensitizes β-cells to apoptosis()
por: Patel, Dhaval, et al.
Publicado: (2015)

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes
por: Eizirik, Decio L., et al.
Publicado: (2021)

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance
por: Colli, Maikel L., et al.
Publicado: (2011)

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance
por: Miani, M, et al.
Publicado: (2013)

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells
por: Grieco, Fabio Arturo, et al.
Publicado: (2017)

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
por: Eizirik, Décio L., et al.
Publicado: (2012)

BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced Apoptosis
por: Perez-Serna, Atenea A., et al.
Publicado: (2023)

The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
por: Ramos-Rodríguez, Mireia, et al.
Publicado: (2019)

Profile of differentially expressed genes mediated by the type III epidermal growth factor receptor mutation expressed in a small-cell lung cancer cell line
por: Pedersen, M W, et al.
Publicado: (2001)

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity
por: Lytrivi, Maria, et al.
Publicado: (2020)

A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes
por: Luce, Sandrine, et al.
Publicado: (2021)

Bioinformatic identification of FGF, p38-MAPK, and calcium signalling pathways associated with carcinoma in situ in the urinary bladder
por: Herbsleb, Malene, et al.
Publicado: (2008)

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
por: Volkmar, Michael, et al.
Publicado: (2012)

Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies
por: Yi, Xiaoyan, et al.
Publicado: (2022)

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death
por: Arif, Sefina, et al.
Publicado: (2011)

SAT069 Targeting Human β-Cell G Protein-coupled Receptors To Alter Cytokine-mediated Caspase Activation
por: dos Santos, Karina Rodrigues, et al.
Publicado: (2023)

Increased cell motility and invasion upon knockdown of lipolysis stimulated lipoprotein receptor (LSR) in SW780 bladder cancer cells
por: Herbsleb, Malene, et al.
Publicado: (2008)

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes
por: Bosi, Emanuele, et al.
Publicado: (2020)

Functional analysis of the mismatch repair system in bladder cancer
por: Thykjaer, T, et al.
Publicado: (2001)

Gene expression profiling of noninvasive primary urothelial tumours using microarrays
por: Aaboe, M, et al.
Publicado: (2005)

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
por: Brozzi, Flora, et al.
Publicado: (2016)

Correction to ‘Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes’
por: Bosi, Emanuele, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_j2daoc3l1b0u8oh4kivq1d8h37