Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid–Induced ER Stress–Mediated β-Cell Death

OBJECTIVE: We have previously shown that lack of thioredoxin-interacting protein (TXNIP) protects against diabetes and glucotoxicity-induced β-cell apoptosis. Because the role of TXNIP in lipotoxicity is unknown, the goal of the present study was to determine whether TXNIP expression is regulated by...

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Detalles Bibliográficos
Autores principales: Chen, Junqin, Fontes, Ghislaine, Saxena, Geetu, Poitout, Vincent, Shalev, Anath
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809961/
https://www.ncbi.nlm.nih.gov/pubmed/19875615
http://dx.doi.org/10.2337/db09-0949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809961/
https://www.ncbi.nlm.nih.gov/pubmed/19875615
http://dx.doi.org/10.2337/db09-0949

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