Cellular Production of n-3 PUFAs and Reduction of n-6–to–n-3 Ratios in the Pancreatic β-Cells and Islets Enhance Insulin Secretion and Confer Protection Against Cytokine-Induced Cell Death

OBJECTIVE: To evaluate the direct impact of n-3 polyunsaturated fatty acids (n-3 PUFAs) on the functions and viability of pancreatic β-cells. RESEARCH DESIGN AND METHODS: We developed an mfat-1 transgenic mouse model in which endogenous production of n-3 PUFAs was achieved through overexpressing a C...

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Detalles Bibliográficos
Autores principales: Wei, Dong, Li, Jie, Shen, Miaoda, Jia, Wei, Chen, Nuoqi, Chen, Tao, Su, Dongming, Tian, Haoming, Zheng, Shusen, Dai, Yifan, Zhao, Allan
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809969/
https://www.ncbi.nlm.nih.gov/pubmed/19933995
http://dx.doi.org/10.2337/db09-0284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809969/
https://www.ncbi.nlm.nih.gov/pubmed/19933995
http://dx.doi.org/10.2337/db09-0284

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