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Cellular Production of n-3 PUFAs and Reduction of n-6–to–n-3 Ratios in the Pancreatic β-Cells and Islets Enhance Insulin Secretion and Confer Protection Against Cytokine-Induced Cell Death
OBJECTIVE: To evaluate the direct impact of n-3 polyunsaturated fatty acids (n-3 PUFAs) on the functions and viability of pancreatic β-cells. RESEARCH DESIGN AND METHODS: We developed an mfat-1 transgenic mouse model in which endogenous production of n-3 PUFAs was achieved through overexpressing a C...
Autores principales: | Wei, Dong, Li, Jie, Shen, Miaoda, Jia, Wei, Chen, Nuoqi, Chen, Tao, Su, Dongming, Tian, Haoming, Zheng, Shusen, Dai, Yifan, Zhao, Allan |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809969/ https://www.ncbi.nlm.nih.gov/pubmed/19933995 http://dx.doi.org/10.2337/db09-0284 |
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