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A Point Mutation in Sec61α1 Leads to Diabetes and Hepatosteatosis in Mice

OBJECTIVE: Type 2 diabetes is caused by both environmental and genetic factors. To better understand the genetic factors we used forward genetics to discover genes that have not previously been implicated in the development of hyperglycemia or diabetes. RESEARCH DESIGN AND METHODS: Offspring of ethy...

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Detalles Bibliográficos
Autores principales: Lloyd, David J., Wheeler, Matthew C., Gekakis, Nicholas
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809972/
https://www.ncbi.nlm.nih.gov/pubmed/19934005
http://dx.doi.org/10.2337/db08-1362