Mutational Analysis of Highly Conserved Residues in the Phage PhiC31 Integrase Reveals Key Amino Acids Necessary for the DNA Recombination

BACKGROUND: Amino acid sequence alignment of phage phiC31 integrase with the serine recombinases family revealed highly conserved regions outside the catalytic domain. Until now, no system mutational or biochemical studies have been carried out to assess the roles of these conserved residues in the...

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Detalles Bibliográficos
Autores principales: Liu, Shaohui, Ma, Jinfang, Wang, Wei, Zhang, Maoxiang, Xin, Qingting, Peng, Siman, Li, Rongxiu, Zhu, Huanzhang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810336/
https://www.ncbi.nlm.nih.gov/pubmed/20111606
http://dx.doi.org/10.1371/journal.pone.0008863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810336/
https://www.ncbi.nlm.nih.gov/pubmed/20111606
http://dx.doi.org/10.1371/journal.pone.0008863

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