The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression

Parafibromin, a component of the RNA polymerase II-associated PAF1 complex, is a tumor suppressor linked to hyperparathyroidism-jaw tumor syndrome and sporadic parathyroid carcinoma. Parafibromin induces cell cycle arrest by repressing cyclin D1 via an unknown mechanism. Here, we show that parafibro...

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Detalles Bibliográficos
Autores principales: Yang, Yong-Jin, Han, Jeung-Whan, Youn, Hong-Duk, Cho, Eun-Jung
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811029/
https://www.ncbi.nlm.nih.gov/pubmed/19906718
http://dx.doi.org/10.1093/nar/gkp991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811029/
https://www.ncbi.nlm.nih.gov/pubmed/19906718
http://dx.doi.org/10.1093/nar/gkp991

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