PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes damaged mitochondria, however, is unknown. Here, we...

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Detalles Bibliográficos
Autores principales: Narendra, Derek P., Jin, Seok Min, Tanaka, Atsushi, Suen, Der-Fen, Gautier, Clement A., Shen, Jie, Cookson, Mark R., Youle, Richard J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811155/
https://www.ncbi.nlm.nih.gov/pubmed/20126261
http://dx.doi.org/10.1371/journal.pbio.1000298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811155/
https://www.ncbi.nlm.nih.gov/pubmed/20126261
http://dx.doi.org/10.1371/journal.pbio.1000298

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