Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

The molecular triggers for axon degeneration remain unknown. We identify endogenous Nmnat2 as a labile axon survival factor whose constant replenishment by anterograde axonal transport is a limiting factor for axon survival. Specific depletion of Nmnat2 is sufficient to induce Wallerian-like degener...

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Detalles Bibliográficos
Autores principales: Gilley, Jonathan, Coleman, Michael P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811159/
https://www.ncbi.nlm.nih.gov/pubmed/20126265
http://dx.doi.org/10.1371/journal.pbio.1000300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811159/
https://www.ncbi.nlm.nih.gov/pubmed/20126265
http://dx.doi.org/10.1371/journal.pbio.1000300

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