Improved Reconstruction of In Silico Gene Regulatory Networks by Integrating Knockout and Perturbation Data

We performed computational reconstruction of the in silico gene regulatory networks in the DREAM3 Challenges. Our task was to learn the networks from two types of data, namely gene expression profiles in deletion strains (the ‘deletion data’) and time series trajectories of gene expression after som...

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Detalles Bibliográficos
Autores principales: Yip, Kevin Y., Alexander, Roger P., Yan, Koon-Kiu, Gerstein, Mark
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811182/
https://www.ncbi.nlm.nih.gov/pubmed/20126643
http://dx.doi.org/10.1371/journal.pone.0008121