Huntingtin Interacts with the Cue Domain of gp78 and Inhibits gp78 Binding to Ubiquitin and p97/VCP

Huntington's disease (HD) is caused by polyglutamine expansion in huntingtin (htt) protein, but the exact mechanism of HD pathogenesis remains uncertain. Recent evidence suggests that htt proteins with expanded polyglutamine tracts induce endoplasmic reticulum (ER) stress, probably by interferi...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Hui, Liu, Chao, Zhong, Yongwang, Luo, Shouqing, Monteiro, Mervyn J., Fang, Shengyun
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811200/
https://www.ncbi.nlm.nih.gov/pubmed/20126661
http://dx.doi.org/10.1371/journal.pone.0008905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811200/
https://www.ncbi.nlm.nih.gov/pubmed/20126661
http://dx.doi.org/10.1371/journal.pone.0008905

Ejemplares similares