In vitro reconstruction of tetronate RK-682 biosynthesis

The protein phosphatase inhibitor RK-682 is one of a number of potentially valuable tetronate polyketide natural products. Understanding how the tetronate ring is formed has been frustrated by the inaccessibility of the putative substrates. We report the heterologous expression of rk genes in Saccha...

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Detalles Bibliográficos
Autores principales: Sun, Yuhui, Hahn, Frank, Demydchuk, Yuliya, Chettle, James, Tosin, Manuela, Osada, Hiroyuki, Leadlay, Peter F.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811812/
https://www.ncbi.nlm.nih.gov/pubmed/20081823
http://dx.doi.org/10.1038/nchembio.285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811812/
https://www.ncbi.nlm.nih.gov/pubmed/20081823
http://dx.doi.org/10.1038/nchembio.285

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