Synaptic and Endosomal Localization of Active γ-Secretase in Rat Brain

BACKGROUND: A key player in the development of Alzheimer's disease (AD) is the γ-secretase complex consisting of at least four components: presenilin, nicastrin, Aph-1 and Pen-2. γ-Secretase is crucial for the generation of the neurotoxic amyloid β-peptide (Aβ) but also takes part in the proces...

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Detalles Bibliográficos
Autores principales: Frykman, Susanne, Hur, Ji-Yeun, Frånberg, Jenny, Aoki, Mikio, Winblad, Bengt, Nahalkova, Jarmila, Behbahani, Homira, Tjernberg, Lars O.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812513/
https://www.ncbi.nlm.nih.gov/pubmed/20126630
http://dx.doi.org/10.1371/journal.pone.0008948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812513/
https://www.ncbi.nlm.nih.gov/pubmed/20126630
http://dx.doi.org/10.1371/journal.pone.0008948

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