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Pincher-generated Nogo-A endosomes mediate growth cone collapse and retrograde signaling
Nogo-A is one of the most potent myelin-associated inhibitors for axonal growth, regeneration, and plasticity in the adult central nervous system. The Nogo-A–specific fragment NogoΔ20 induces growth cone collapse, and inhibits neurite outgrowth and cell spreading by activating RhoA. Here, we show th...
Autores principales: | Joset, Armela, Dodd, Dana A., Halegoua, Simon, Schwab, Martin E. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812518/ https://www.ncbi.nlm.nih.gov/pubmed/20083601 http://dx.doi.org/10.1083/jcb.200906089 |
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