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Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-L(S) substrates
Sophisticated quality control mechanisms prolong retention of protein-folding intermediates in the endoplasmic reticulum (ER) until maturation while sorting out terminally misfolded polypeptides for ER-associated degradation (ERAD). The presence of structural lesions in the luminal, transmembrane, o...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812524/ https://www.ncbi.nlm.nih.gov/pubmed/20100910 http://dx.doi.org/10.1083/jcb.200910042 |