VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification

Neutrophils kill microbes with reactive oxygen species generated by the NADPH oxidase, an enzyme which moves electrons across membranes. Voltage-gated proton channels (voltage-sensing domain only protein [VSOP]/Hv1) are required for high-level superoxide production by phagocytes, but the mechanism o...

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Detalles Bibliográficos
Autores principales: El Chemaly, Antoun, Okochi, Yoshifumi, Sasaki, Mari, Arnaudeau, Serge, Okamura, Yasushi, Demaurex, Nicolas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812533/
https://www.ncbi.nlm.nih.gov/pubmed/20026664
http://dx.doi.org/10.1084/jem.20091837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812533/
https://www.ncbi.nlm.nih.gov/pubmed/20026664
http://dx.doi.org/10.1084/jem.20091837

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