Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

Progranulin (PGRN) is a widely expressed protein involved in diverse biological processes. Haploinsufficiency of PGRN in the human causes tau-negative, ubiquitin-positive frontotemporal dementia (FTD). However, the mechanisms are unknown. To explore the role of PGRN in vivo, we generated PGRN-defici...

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Detalles Bibliográficos
Autores principales: Yin, Fangfang, Banerjee, Rebecca, Thomas, Bobby, Zhou, Ping, Qian, Liping, Jia, Ting, Ma, Xiaojing, Ma, Yao, Iadecola, Costantino, Beal, M. Flint, Nathan, Carl, Ding, Aihao
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812536/
https://www.ncbi.nlm.nih.gov/pubmed/20026663
http://dx.doi.org/10.1084/jem.20091568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812536/
https://www.ncbi.nlm.nih.gov/pubmed/20026663
http://dx.doi.org/10.1084/jem.20091568

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