Cargando…
Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID
High-affinity antibodies are generated by somatic hypermutation with nucleotide substitutions introduced into the IgV in a semirandom fashion, but with intrinsic mutational hotspots strategically located to optimize antibody affinity maturation. The process is dependent on activation-induced deamina...
| Autores principales: | , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812546/ https://www.ncbi.nlm.nih.gov/pubmed/20048284 http://dx.doi.org/10.1084/jem.20092238 |